Detalhe da pesquisa
1.
The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer.
Cell
; 184(12): 3143-3162.e32, 2021 06 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34004147
2.
Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition.
Mol Cell
; 81(10): 2183-2200.e13, 2021 05 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-34019788
3.
Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis.
EMBO J
; 39(21): e105111, 2020 11 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32945574
4.
Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population.
Blood
; 129(21): 2882-2895, 2017 05 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-28283481
5.
Targeting the nucleolus for cancer intervention.
Biochim Biophys Acta
; 1842(6): 802-16, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24389329
6.
Combined inhibition of PI3K-related DNA damage response kinases and mTORC1 induces apoptosis in MYC-driven B-cell lymphomas.
Blood
; 121(15): 2964-74, 2013 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-23403624
7.
More than a Tumor Suppressor: E-Cadherin Loss Drives Lung Cancer Metastasis.
Am J Respir Cell Mol Biol
; 59(2): 141-142, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29688752
8.
Targeting transcription cycles in cancer.
Nat Rev Cancer
; 22(1): 5-24, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34675395
9.
Development of an adenosquamous carcinoma histopathology - selective lung metastasis model.
Biol Open
; 11(12)2022 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36355420
10.
Serine Biosynthesis Is a Metabolic Vulnerability in FLT3-ITD-Driven Acute Myeloid Leukemia.
Cancer Discov
; 11(6): 1582-1599, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33436370
11.
CDK13 cooperates with CDK12 to control global RNA polymerase II processivity.
Sci Adv
; 6(18)2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32917631
12.
A novel CDK9 inhibitor increases the efficacy of venetoclax (ABT-199) in multiple models of hematologic malignancies.
Leukemia
; 34(6): 1646-1657, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31827241
13.
Receptor Tyrosine Kinase Signaling Networks Define Sensitivity to ERBB Inhibition and Stratify Kras-Mutant Lung Cancers.
Mol Cancer Ther
; 18(10): 1863-1874, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31320402
14.
Cell of Origin Links Histotype Spectrum to Immune Microenvironment Diversity in Non-small-Cell Lung Cancer Driven by Mutant Kras and Loss of Lkb1.
Cell Rep
; 18(3): 673-684, 2017 01 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-28099846
15.
The Dual Inhibition of RNA Pol I Transcription and PIM Kinase as a New Therapeutic Approach to Treat Advanced Prostate Cancer.
Clin Cancer Res
; 22(22): 5539-5552, 2016 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27486174
16.
Combination Therapy Targeting Ribosome Biogenesis and mRNA Translation Synergistically Extends Survival in MYC-Driven Lymphoma.
Cancer Discov
; 6(1): 59-70, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26490423
17.
Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling.
Oncotarget
; 7(31): 49800-49818, 2016 Aug 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27391441
18.
AKT signalling is required for ribosomal RNA synthesis and progression of Eµ-Myc B-cell lymphoma in vivo.
FEBS J
; 280(21): 5307-16, 2013 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-23331925